منابع مشابه
O24: Functional Role of the K2P Potassium Channel TASK-3 in Glioma
TASK-3, a two-pore-domain (K2P) potassium channel, has been implicated as important regulator for the effector function and proliferation of T-cells. Interestingly, TASK-3 has also a functional impact on tumor cells. Therefore, we sought to investigate whether TASK3 modulation might have a therapeutic potential for malignant gliomas by a variety of phenotypical and functional in vitro assays mi...
متن کاملO 24: Functional Role of The K2p Potassium Channel Task-3 in A Syngeneic Murine Glioma Model
To investigate the effects of the two-pore-domain potassium (K2P) channel TASK-3 in a syngeneic murine model for malignant glioma. Malignant or high-grade glioma (WHO grade III and IV) are the most common and most aggressive primary brain tumors in adults. Despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. However, recent phase I and II trials hav...
متن کاملGlioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy.
Big potassium (BK) ion channels have several spliced variants. One spliced variant initially described within human glioma cells is the glioma BK (gBK) channel. This isoform consists of 34 aa inserted into the intracellular region of the basic BK ion channel. PCR primers specific for this inserted region confirmed that human glioma cell lines and freshly resected surgical tissues from glioblast...
متن کاملo 24: functional role of the k2p potassium channel task-3 in a syngeneic murine glioma model
to investigate the effects of the two-pore-domain potassium (k2p) channel task-3 in a syngeneic murine model for malignant glioma. malignant or high-grade glioma (who grade iii and iv) are the most common and most aggressive primary brain tumors in adults. despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. however, recent phase i and ii trials hav...
متن کاملCyclic AMP regulates potassium channel expression in C6 glioma by destabilizing Kv1.1 mRNA.
The tissue distributions and physiological properties of a variety of cloned voltage-gated potassium channel genes have been characterized extensively, yet relatively little is known about the mechanisms controlling expression of these genes. Here, we report studies on the regulation of Kv1.1 expressed endogenously in the C6 glioma cell line. We demonstrate that elevation of intracellular cAMP ...
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ژورنال
عنوان ژورنال: Biomedical Journal of Scientific & Technical Research
سال: 2019
ISSN: 2574-1241
DOI: 10.26717/bjstr.2019.16.002879